Age-related macular degeneration — Vaccinia virus complement control protein (VCP)

Low-dose IL2 raises regulatory T cells, which reverse protein loss in the urine in animal models of nephrotic syndrome, so it would lower protein loss in children whose nephrotic syndrome resists all other drugs.

In 5 boys given six monthly cycles, IL2 raised regulatory T cells in some, but protein in the urine and kidney function did not change at any point. One child had an asthma attack after the first dose.

Why it matched: mechanism: Inflammation & innate immunity · failed the same way: Held in the model species, not beyond it

The neutrophils that flood the airways in severe RSV infection would contribute to controlling the virus, to lung inflammation, or to how sick the host becomes.

In RSV-infected mice, antibody depletion of neutrophils did not substantially change type I interferons, IL-6, TNF-alpha or IL-1beta, nor viral load. Neither depleting neutrophils nor boosting them with CXCL1 changed peak disease severity measured by weight loss.

Why it matched: mechanism: Inflammation & innate immunity · failed the same way: Held in the model species, not beyond it