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Neuroscience› Cognitive Neuroscience› Hemispheric Asymmetry in Neuroscience

Developmental language disorder — Cerebral lateralisation (handedness and fTCD language laterality)

Submitted 2026-10-22

Field: Neuroscience › Cognitive NeuroscienceType: Couldn't replicate a published resultArea: developmental language disorderTarget: Cerebral lateralisation (handedness and fTCD language laterality)Stage: replication

Hypothesis

Children with developmental language disorder would show weaker hand preference and less left-lateralised language, as earlier studies reported.

What failed

In 107 twin children with DLD and 156 typically developing twins aged 6–11, there were no group differences in handedness, functional transcranial Doppler language laterality, or consistency of left-hemisphere dominance. Right-lateralised language was in fact more common in the typically developing group (19.9% vs 9.3%), and links between laterality and language scores also did not replicate.

Broken assumption

Failure to establish typical left-hemisphere lateralisation is part of what goes wrong in developmental language disorder.

Why

Given the large sample and range of measures, the authors suggest earlier reports of atypical lateralisation in DLD may have been false positives.

From the published paper: Wilson et al. PeerJ, 2018. ↗CC BY

Research ideas from this failure

Unvetted lead — read the papers

New hypotheses this failure suggests, each with a crucial experiment, a rival explanation of the original result, and the papers it rests on. Written by AI from paper titles and abstracts found on OpenAlex (and Europe PMC, for life and health sciences).

Related failures (2)

Matched on shared genes, mechanisms and ways of failing as well as wording. Each shows why it matched — treat these as leads rather than verdicts.

Links in published research

Where this experiment's genes are known to matter outside its own research area, and the papers behind those links. Sources: Open Targets Platform and Europe PMC.