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Neuroscience› Neurology› Transcranial Magnetic Stimulation Studies

Non-invasive brain stimulation — Alpha-frequency transcranial alternating current stimulation (multi-electrode montage)

Submitted 2026-10-22

Field: Neuroscience › NeurologyType: Couldn't replicate a published resultArea: non-invasive brain stimulationTarget: Alpha-frequency transcranial alternating current stimulation (multi-electrode montage)Stage: replication

Hypothesis

Alpha entrainment by tACS, reported with an anterior/posterior two-electrode montage, would be robust enough to survive scaling up to a multi-electrode montage and changes in the participants' background task, raising subsequent alpha power.

What failed

A multi-electrode analogue of the earlier anterior/posterior stimulation, given while background tasks varied, did not reproduce the reported alpha entrainment: subsequent alpha power was not modulated.

Broken assumption

tACS alpha after-effects are robust to task context and to moving from two-electrode to multi-electrode montages.

Why

The abstract gives no mechanism; the authors say more work is needed to define when tACS alpha entrainment applies.

From the published paper: Fekete et al. Frontiers in Neuroscience, 2018. ↗CC BY

Research ideas from this failure

Unvetted lead — read the papers

New hypotheses this failure suggests, each with a crucial experiment, a rival explanation of the original result, and the papers it rests on. Written by AI from paper titles and abstracts found on OpenAlex (and Europe PMC, for life and health sciences).

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Links in published research

Where this experiment's genes are known to matter outside its own research area, and the papers behind those links. Sources: Open Targets Platform and Europe PMC.