Medicine› Rheumatology› Rheumatoid Arthritis Research and Therapies

Rheumatoid arthritis — JAK1

Submitted 2026-10-18

Field: Medicine › RheumatologyIllustrative exampleArea: rheumatoid arthritisTarget: JAK1Stage: preclinical✦ AI inferred reasoning

Hypothesis

A JAK1-selective inhibitor would retain efficacy in collagen-induced arthritis while avoiding pan-JAK haematologic effects.

What failed

Efficacy held in rat models but the therapeutic window closed in dog toxicology before an efficacious exposure was reached.

Why

Species differences in JAK1 dependence made the rodent window misleading; the programme stopped on narrow therapeutic index rather than on any efficacy finding.

Research ideas from this failure

Unvetted lead — read the papers

New hypotheses this failure suggests, each with a crucial experiment, a rival explanation of the original result, and the papers it rests on. Written by AI from paper titles and abstracts found on OpenAlex (and Europe PMC, for life and health sciences).

Not available for example entries: this one describes an invented experiment, and ideas built on it would be fiction.

Related failures

Nothing else logged looks close to this one yet.

Links in published research

Where this experiment's genes are known to matter outside its own research area, and the papers behind those links. Sources: Open Targets Platform and Europe PMC.