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Neuroscience› Cognitive Neuroscience› Sleep and Wakefulness Research

Sleep and memory — Targeted memory reactivation during NREM sleep in adolescents

Submitted 2026-10-22

Field: Neuroscience › Cognitive NeuroscienceType: No effect foundArea: sleep and memoryTarget: Targeted memory reactivation during NREM sleep in adolescentsStage: full study

Hypothesis

Replaying newly learned foreign words during sleep would boost recall in 11–13-year-olds even more than in adults, because slow-oscillation activity peaks in adolescence.

What failed

Words cued by loudspeaker during post-learning NREM sleep were not recalled better the next morning than uncued words. Frontal theta power rose with successful cueing as in adults, but the expected spindle-power increase did not appear.

Broken assumption

More slow-oscillation activity during sleep means cued memory reactivation works better.

Why

The paper does not settle the cause; it discusses adolescents' learning abilities and pre-sleep performance levels as possible reasons for the missing effect.

From the published paper: Wilhelm et al. Scientific Reports, 2020. ↗CC BY

Research ideas from this failure

Unvetted lead — read the papers

New hypotheses this failure suggests, each with a crucial experiment, a rival explanation of the original result, and the papers it rests on. Written by AI from paper titles and abstracts found on OpenAlex (and Europe PMC, for life and health sciences).

Related failures

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Links in published research

Where this experiment's genes are known to matter outside its own research area, and the papers behind those links. Sources: Open Targets Platform and Europe PMC.