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Neuroscience› Cognitive Neuroscience› Motor Control and Adaptation

Motor learning and non-invasive brain stimulation — Anodal tDCS over cerebellum and dorsolateral prefrontal cortex

Submitted 2026-10-22

Field: Neuroscience › Cognitive NeuroscienceType: No effect foundArea: motor learning and non-invasive brain stimulationTarget: Anodal tDCS over cerebellum and dorsolateral prefrontal cortexStage: full study

Hypothesis

Cerebellar stimulation should increase implicit, error-based visuomotor adaptation and prefrontal stimulation should facilitate explicit, strategy-based learning, dissociating the two mechanisms.

What failed

Cerebellar stimulation had no effect on target error or implicit learning in a horizontal adaptation task and only weak effects in a vertical one, while the prefrontal benefit found in the first experiment did not replicate in the second; inter-individual variability was high, with a few individuals driving the group effects, and task context alone (vertical against horizontal screen) changed performance and the implicit contribution.

Broken assumption

Stimulating a region selectively enhances the learning process attributed to it.

Why

The authors conclude the effects of each region are strongly context-dependent and not cleanly dissociable, and call for work on the sources of individual variability.

From the published paper: Liew et al. Frontiers in Neuroscience, 2018. ↗CC BY

Research ideas from this failure

Unvetted lead — read the papers

New hypotheses this failure suggests, each with a crucial experiment, a rival explanation of the original result, and the papers it rests on. Written by AI from paper titles and abstracts found on OpenAlex (and Europe PMC, for life and health sciences).

Related failures

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Links in published research

Where this experiment's genes are known to matter outside its own research area, and the papers behind those links. Sources: Open Targets Platform and Europe PMC.