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Neuroscience› Cognitive Neuroscience› Neuroscience and Music Perception

Cognitive neuroscience of ageing — Musicianship and brain-age gap (BrainAGE)

Submitted 2026-10-22

Field: Neuroscience › Cognitive NeuroscienceType: Couldn't replicate a published resultArea: cognitive neuroscience of ageingTarget: Musicianship and brain-age gap (BrainAGE)Stage: replication

Hypothesis

Following an earlier BrainAGE study, musicians, and people with more musical training or active musical engagement, would have younger-looking brains than non-musicians.

What failed

In 125 scanned healthy adults, musician status was unrelated to BrainAGE score, and neither the musical-training nor the active-engagement subscale of the Gold-MSI predicted it; current physical activity did.

Broken assumption

Playing or engaging with music is enough on its own to make the brain look measurably younger.

Why

The abstract gives no explanation for the non-replication; the authors instead report that musical behaviours relate to a resilience factor.

From the published paper: Matziorinis et al. Brain Structure and Function, 2022. ↗CC BY

Research ideas from this failure

Unvetted lead — read the papers

New hypotheses this failure suggests, each with a crucial experiment, a rival explanation of the original result, and the papers it rests on. Written by AI from paper titles and abstracts found on OpenAlex (and Europe PMC, for life and health sciences).

Related failures

Nothing else logged looks close to this one yet.

Links in published research

Where this experiment's genes are known to matter outside its own research area, and the papers behind those links. Sources: Open Targets Platform and Europe PMC.