Field: Medicine › Endocrinology, Diabetes and MetabolismType: No effect foundArea: type 2 diabetesTarget: 12-week endurance exercise with or without vitamin D supplementationStage: randomized trial
Hypothesis
Twelve weeks of endurance exercise, vitamin D, or both would reduce insulin resistance (HOMA-IR) in middle-aged adults with type 2 diabetes.
What failed
Across 61 participants randomised to control, exercise, vitamin D or both, none of the interventions improved HOMA-IR, the primary outcome; only fasting glucose fell in the combined group (−11.9%).
Broken assumption
Endurance exercise and vitamin D lower insulin resistance in type 2 diabetes within 12 weeks.
Why
The authors suggest the null primary result may be due predominantly to large inter-individual variability in response, which baseline plasma lipids predicted well in exploratory models.
From the published paper: Sun et al. Nutrients, 2023. ↗CC BY