Heart failure — Adaptive servo-ventilation

Spironolactone, which improves outcomes in heart failure with reduced ejection fraction, would do the same in heart failure with preserved ejection fraction.

In 3,445 patients with ejection fraction of 45% or more over a mean 3.3 years, the primary composite (cardiovascular death, aborted cardiac arrest or heart-failure hospitalization) occurred in 18.6% vs 20.4% on placebo (HR 0.89, P=0.14). Hyperkalemia doubled (18.7% vs 9.1%).

Why it matched: similar wording · same research area

Clearing the parasite with benznidazole in patients with established Chagas cardiomyopathy would slow cardiac clinical deterioration.

Among 2,854 patients followed a mean 5.4 years, the composite cardiac outcome occurred in 27.5% vs 29.1% on placebo (HR 0.93, P=0.31).

Why it matched: same research area

Bringing triglycerides down to target within 72 hours of admission would improve outcomes in hypertriglyceridemic acute pancreatitis, and higher admission triglycerides would mean more severe disease.

In 345 retrospectively studied patients, those who reached the early TG goal (274) and those who did not (71) did not differ in pancreatic necrosis, length of stay or in-hospital mortality. The highest admission TG levels did not track the most severe disease, and neither admission TG nor the size of the 72-hour reduction correlated with necrosis.

Why it matched: similar wording · failed the same way: Target engaged, outcome unchanged