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Agricultural and Biological Sciences› Agronomy and Crop Science› Animal Disease Management and Epidemiology

African swine fever — CD2-like gene 8DR (EP402R) of African swine fever virus

Submitted 2026-10-22

Field: Agricultural and Biological Sciences › Agronomy and Crop ScienceType: No effect foundArea: african swine feverTarget: CD2-like gene 8DR (EP402R) of African swine fever virusStage: preclinical

Hypothesis

Deleting the CD2-like 8DR gene would weaken the virulent ASFV Georgia2010 isolate, since several naturally non-hemadsorbing field isolates are less virulent in pigs.

What failed

Pigs inoculated intramuscularly or intranasally with the deletion mutant at 10^2 to 10^4 TCID50 developed disease indistinguishable from that caused by the parental virus, and viraemia levels did not differ.

Broken assumption

The CD2-like gene is what makes naturally non-hemadsorbing ASFV isolates less virulent.

Why

The authors conclude the gene is not responsible for the reduced virulence of natural non-hemadsorbing isolates, so their attenuation must come from something else.

From the published paper: Borca et al. Scientific Reports, 2020. ↗CC BY

Research ideas from this failure

Unvetted lead — read the papers

New hypotheses this failure suggests, each with a crucial experiment, a rival explanation of the original result, and the papers it rests on. Written by AI from paper titles and abstracts found on OpenAlex (and Europe PMC, for life and health sciences).

Related failures

Nothing else logged looks close to this one yet.

Links in published research

Where this experiment's genes are known to matter outside its own research area, and the papers behind those links. Sources: Open Targets Platform and Europe PMC.